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_iron-man-4-crossing-worlds-2025-trailer---robert-downey-jr.jpg "This trailer is created solely for creative purposes and is not affiliated with the official marketing of the film. We are inspired by cinema and invite you on an exciting journey into the world of our ideas and fantasies. Enjoy the viewing and subscribe to the channel for more content!<br/>____________________________________________<br/><br/>In this thrilling new chapter, Tony Stark returns from another multiverse, bringing with him a wealth of new experiences and challenges. As he navigates this unfamiliar world, Tony encounters old friends and new allies, each bringing their unique strengths to the table. Among these allies, Doctor Strange stands out as the most crucial, guiding Tony through the complexities of the multiverse and helping him face unprecedented threats. Get ready for an epic adventure as Iron Man and Doctor Strange join forces to protect their world from the dangers lurking beyond reality.<br/>________________")
⏲ 1:18 👁 15K
_92.jpg "\ from med ki nay crossing")
⏲ 8:5 👁 10K
_chickens-crossing-the-road.jpg "️#CHICKENS CROSSING THE ROAD️ from med ki nay crossing")
⏲ 0:27 👁 10K
_my-little-girl-episode-31-long-version.jpg "Oyku (Beren Gokyildiz) is an 8-year-old girl who has a very clear perception and is very smart, unlike her peers. When her aunt, with whom she has lived since birth, leaves her, she has to find her father Demir, whom she has never seen before. Demir (Bugra Gulsoy), a fraudster who grew up in an orphanage, is arrested on the day that Oyku comes to find him. Demir is released by the court on condition that he takes care of his daughter, but Demir does not want to live with Oyku. While Demir and his partner Ugur (Tugay Mercan) are trying to get rid of Oyku, they are planning to make a big hit. Candan (Leyla Lydia Tugutlu), who is the target of this great hit, hides the great pains of the past in her calm life. None of these people whom life will bring together with all these coincidences know that Oyku is hiding a great secret.<br/><br/>CAST: Bugra Gulsoy, Leyla Lydia Tugutlu, Beren Gokyildiz, Serhat Teoman, Tugay Mercan, Sinem Unsal, Suna Selen.<br/><br/>CREDITS<br/>PRODUCTION COMPANY: MED Yapim<br/>PRODUCER: Fatih Aksoy<br/>DIRECTOR: Gokcen Usta<br/>")
⏲ 1:35:25 👁 10K
![About this item<br/>Pixel Buds Pro use Active Noise Cancellation with Silent Seal to adapt to your ear and help block outside sounds, creating a quiet foundation so your music can shine; and now they’re even better, with new features and colors<br/>With double the bandwidth for clearer calls, Pixel Buds Pro are the perfect earbuds for Pixel[11]<br/>Pairs with any Bluetooth 4.0+ device, including Android, iOS, tablets, and laptops[1]; and multipoint connectivity helps you switch between compatible devices, so you can go from listening to music on your phone to taking a call on your laptop[2]<br/>Pixel Buds Pro have custom 11 mm speaker drivers and Volume EQ to sound amazing at any volume[3]; the app tells you how loud you’ve been listening to music over time and offers ways to adjust to help you maintain your hearing wellness<br/>Gaming audio now reaches your ears up to 2x faster on average; when you start a game, your earbuds automatically switch to gaming mode, cutting latency in half[4]<br/>The battery keeps up with your life, with up to 11 hours of listening time, or up to 31 hours with the charging case[5]; you can charge them wirelessly with Pixel Stand or other Qi-certified chargers[6]<br/>Transparency mode helps you hear outside sounds in real time so you can be more aware of your surroundings, like when crossing the street; Conversation Detection pauses your music and your earbuds switch to Transparency mode when you start speaking<br/>Show more<br/> Report an issue with this product or seller<br/>Note: Products with electrical plugs are designed for use in the US. Outlets and voltage differ internationally and this product may require an adapter or converter for use in your destination. Please check compatibility before purchasing.](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHUEIGmSwGmEDBS9DFGWlAP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_amazon-com-google-pixel-buds-pro-noise-canceling-earbuds-up-to-31-hour-battery-life-with-charging-case2-bluetooth.jpg "About this item<br/>Pixel Buds Pro use Active Noise Cancellation with Silent Seal to adapt to your ear and help block outside sounds, creating a quiet foundation so your music can shine; and now they’re even better, with new features and colors<br/>With double the bandwidth for clearer calls, Pixel Buds Pro are the perfect earbuds for Pixel[11]<br/>Pairs with any Bluetooth 4.0+ device, including Android, iOS, tablets, and laptops[1]; and multipoint connectivity helps you switch between compatible devices, so you can go from listening to music on your phone to taking a call on your laptop[2]<br/>Pixel Buds Pro have custom 11 mm speaker drivers and Volume EQ to sound amazing at any volume[3]; the app tells you how loud you’ve been listening to music over time and offers ways to adjust to help you maintain your hearing wellness<br/>Gaming audio now reaches your ears up to 2x faster on average; when you start a game, your earbuds automatically switch to gaming mode, cutting latency in half[4]<br/>The battery keeps up with your life, with up to 11 hours of listening time, or up to 31 hours with the charging case[5]; you can charge them wirelessly with Pixel Stand or other Qi-certified chargers[6]<br/>Transparency mode helps you hear outside sounds in real time so you can be more aware of your surroundings, like when crossing the street; Conversation Detection pauses your music and your earbuds switch to Transparency mode when you start speaking<br/>Show more<br/> Report an issue with this product or seller<br/>Note: Products with electrical plugs are designed for use in the US. Outlets and voltage differ internationally and this product may require an adapter or converter for use in your destination. Please check compatibility before purchasing.")
⏲ 0:30 👁 10K
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.jpg "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
⏲ 1:42 👁 10K
_biden-signs-executive-order-capping-number-of-asylum-seekers-at-us-mexico-border.jpg "Biden Signs Executive Order , Capping Number of <br/>Asylum Seekers , at US-Mexico Border.<br/>Biden Signs Executive Order , Capping Number of <br/>Asylum Seekers , at US-Mexico Border.<br/>On June 4, President Joe Biden signed an <br/>executive order restricting asylum seekers <br/>at the United States' border with Mexico.<br/>On June 4, President Joe Biden signed an <br/>executive order restricting asylum seekers <br/>at the United States' border with Mexico.<br/>'Newsweek' report that the executive order utilizes <br/>a controversial regulation last used by his <br/>predecessor, former President Donald Trump.<br/>'Newsweek' report that the executive order utilizes <br/>a controversial regulation last used by his <br/>predecessor, former President Donald Trump.<br/>The executive order will effectively halt migrants crossing <br/>the U.S. border once a daily cap of 2,500 crossings per <br/>day over a seven-day average has been reached. .<br/>The executive order will effectively halt migrants crossing <br/>the U.S. border once a daily cap of 2,500 crossings per <br/>day over a seven-day average has been reached. .<br/>It also allows officials to rapidly deport <br/>migrants who cross the border illegally.<br/>We will need to review the executive <br/>order before making litigation <br/>decisions, but any policy that <br/>effectively shuts off asylum would <br/>raise obvious legal problems,<br/> just as we did when the Trump <br/>administration tried to end asylum,Lee Gelernt, Deputy director of the ACLU's <br/>Immigrants' Rights Project, via 'Newsweek'.<br/>'Newsweek' reports that the executive order <br/>marks a significant shift in the Biden <br/>administration's immigration policy. .<br/>'Newsweek' reports that the executive order <br/>marks a significant shift in the Biden <br/>administration's immigration policy. .<br/>The executive order utilizes a law referred to as Section <br/>212(f), which dates back to the 1950s, and was last used <br/>by Donald Trump at the beginning of his presidency. .<br/>The executive order utilizes a law referred to as Section <br/>212(f), which dates back to the 1950s, and was last used <br/>by Donald Trump at the beginning of his presidency. .<br/>The measure allows the president to <br/>suspend the entry of any foreigner deemed <br/>\")
⏲ 1:31 👁 14.2M
_my-little-girl-episode-27-long-version.jpg "Oyku (Beren Gokyildiz) is an 8-year-old girl who has a very clear perception and is very smart, unlike her peers. When her aunt, with whom she has lived since birth, leaves her, she has to find her father Demir, whom she has never seen before. Demir (Bugra Gulsoy), a fraudster who grew up in an orphanage, is arrested on the day that Oyku comes to find him. Demir is released by the court on condition that he takes care of his daughter, but Demir does not want to live with Oyku. While Demir and his partner Ugur (Tugay Mercan) are trying to get rid of Oyku, they are planning to make a big hit. Candan (Leyla Lydia Tugutlu), who is the target of this great hit, hides the great pains of the past in her calm life. None of these people whom life will bring together with all these coincidences know that Oyku is hiding a great secret.<br/><br/>CAST: Bugra Gulsoy, Leyla Lydia Tugutlu, Beren Gokyildiz, Serhat Teoman, Tugay Mercan, Sinem Unsal, Suna Selen.<br/><br/>CREDITS<br/>PRODUCTION COMPANY: MED Yapim<br/>PRODUCER: Fatih Aksoy<br/>DIRECTOR: Gokcen Usta")
⏲ 1:39:27 👁 15K
_mein-episode-09.jpg "Mein-Episode-09<br/><br/>Mein | The Quest Of Me With Me<br/><br/>Mein is a dramatic story of two strong-headed individuals who end up crossing paths due to being unlucky in love while facing family and societal pressures!<br/><br/>Directed By: Badar Mehmood<br/>Written By: Zanjabeel Asim Shah<br/><br/>Cast:<br/>Wahaj Ali<br/>Ayeza Khan<br/>Azeekah Daniel<br/>Usman Peerzada<br/>Shehzad Nawaz<br/>Aijaz Aslam<br/>Agha Mustafa<br/>Nameer Khan<br/>Sabeena Syed<br/>Alizay Rasool<br/>Rohi Ghazali<br/>Shiza Khan")
⏲ 38:1 👁 10K
_my-little-girl-episode-29-long-version.jpg "Oyku (Beren Gokyildiz) is an 8-year-old girl who has a very clear perception and is very smart, unlike her peers. When her aunt, with whom she has lived since birth, leaves her, she has to find her father Demir, whom she has never seen before. Demir (Bugra Gulsoy), a fraudster who grew up in an orphanage, is arrested on the day that Oyku comes to find him. Demir is released by the court on condition that he takes care of his daughter, but Demir does not want to live with Oyku. While Demir and his partner Ugur (Tugay Mercan) are trying to get rid of Oyku, they are planning to make a big hit. Candan (Leyla Lydia Tugutlu), who is the target of this great hit, hides the great pains of the past in her calm life. None of these people whom life will bring together with all these coincidences know that Oyku is hiding a great secret.<br/><br/>CAST: Bugra Gulsoy, Leyla Lydia Tugutlu, Beren Gokyildiz, Serhat Teoman, Tugay Mercan, Sinem Unsal, Suna Selen.<br/><br/>CREDITS<br/>PRODUCTION COMPANY: MED Yapim<br/>PRODUCER: Fatih Aksoy<br/>DIRECTOR: Gokcen Usta")
⏲ 1:48:41 👁 10K
_crossing-trailer.jpg "MUBI has released a new trailer and artwork for Levan Akin’s (And Then We Danced, Sweden’s 2019 Academy Award® entry) latest feature film, Crossing. A moving, compassionate tale of identity, acceptance and unlikely connection that transcends borders and generations, the film will be released in cinemas in the UK and Ireland on 19 July 2024.<br/><br/>Lia, a retired school teacher living in Georgia, hears from a young neighbour Achi that her long lost niece Tekla, a transgender woman, has crossed the border into Turkey. Hoping to bring Tekla home after a period of estrangement, Lia travels to Istanbul with the unpredictable Achi to find her. Exploring the hidden depths of the city, they cross paths with a transgender lawyer called Evrim, who helps them in their search. Humanistic and tender, Akin’s third feature is a heartfelt portrayal of overcoming the degrees of separation that divide us.<br/><br/>Written by Akin, Crossing stars Mzia Arabuli, Lucas Kankava and Deniz Dumanlı, with cinematography from Lisabi Fridell (And Then We Danced), production design by Roger Rosenberg (The Worst Person in the World) and co-edited by Levan Akin and Emma Lagrelius.<br/><br/>Crossing opened the Panorama section at the 2024 Berlinale for its World Premiere in February, where it was awarded the Teddy Prize Jury Award and received its UK Premiere at the BFI Flare Film Festival in March 2024.")
⏲ 1:48 👁 10K
_revealing-a-secret-on-nbc39s-chicago-med.jpg "Immerse yourself in the intensity of the “Revealing a Secret” clip from NBC's gripping medical drama, Chicago Med. In Season 9, viewers are drawn into the high-stakes world of the Chicago Med team as they navigate complex medical cases and personal challenges. This season highlights the exceptional storytelling of creators Dick Wolf and Matt Olmstead, known for Law & Order. Featuring a stellar cast including Oliver Platt, Steven Weber, Jessy Schram and more, Chicago Med delivers heart-pounding action and an emotional rollercoaster. Catch the latest episodes of Chicago Med Season 9, now streaming on Peacock!<br/><br/>Chicago Med Cast:<br/><br/>Marlyne Barrett, S. Epatha Merkerson, Oliver Platt, Lorena Diaz, Courtney Rioux, Dominic Rains, Jeremy Shouldis, Steven Weber, Cesar Jaime, Marie Tredway, Luke Mitchell, Henderson Wade and Jessy Schram<br/><br/>Stream Chicago Med Season 9 now on Peacock!")
⏲ 3:18 👁 145K
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_iron-man-4-crossing-worlds-2025-trailer---robert-downey-jr.webp "This trailer is created solely for creative purposes and is not affiliated with the official marketing of the film. We are inspired by cinema and invite you on an exciting journey into the world of our ideas and fantasies. Enjoy the viewing and subscribe to the channel for more content!<br/>____________________________________________<br/><br/>In this thrilling new chapter, Tony Stark returns from another multiverse, bringing with him a wealth of new experiences and challenges. As he navigates this unfamiliar world, Tony encounters old friends and new allies, each bringing their unique strengths to the table. Among these allies, Doctor Strange stands out as the most crucial, guiding Tony through the complexities of the multiverse and helping him face unprecedented threats. Get ready for an epic adventure as Iron Man and Doctor Strange join forces to protect their world from the dangers lurking beyond reality.<br/>________________")
_92.webp "\ from med ki nay crossing")
_chickens-crossing-the-road.webp "️#CHICKENS CROSSING THE ROAD️ from med ki nay crossing")
_my-little-girl-episode-31-long-version.webp "Oyku (Beren Gokyildiz) is an 8-year-old girl who has a very clear perception and is very smart, unlike her peers. When her aunt, with whom she has lived since birth, leaves her, she has to find her father Demir, whom she has never seen before. Demir (Bugra Gulsoy), a fraudster who grew up in an orphanage, is arrested on the day that Oyku comes to find him. Demir is released by the court on condition that he takes care of his daughter, but Demir does not want to live with Oyku. While Demir and his partner Ugur (Tugay Mercan) are trying to get rid of Oyku, they are planning to make a big hit. Candan (Leyla Lydia Tugutlu), who is the target of this great hit, hides the great pains of the past in her calm life. None of these people whom life will bring together with all these coincidences know that Oyku is hiding a great secret.<br/><br/>CAST: Bugra Gulsoy, Leyla Lydia Tugutlu, Beren Gokyildiz, Serhat Teoman, Tugay Mercan, Sinem Unsal, Suna Selen.<br/><br/>CREDITS<br/>PRODUCTION COMPANY: MED Yapim<br/>PRODUCER: Fatih Aksoy<br/>DIRECTOR: Gokcen Usta<br/>")
![About this item<br/>Pixel Buds Pro use Active Noise Cancellation with Silent Seal to adapt to your ear and help block outside sounds, creating a quiet foundation so your music can shine; and now they’re even better, with new features and colors<br/>With double the bandwidth for clearer calls, Pixel Buds Pro are the perfect earbuds for Pixel[11]<br/>Pairs with any Bluetooth 4.0+ device, including Android, iOS, tablets, and laptops[1]; and multipoint connectivity helps you switch between compatible devices, so you can go from listening to music on your phone to taking a call on your laptop[2]<br/>Pixel Buds Pro have custom 11 mm speaker drivers and Volume EQ to sound amazing at any volume[3]; the app tells you how loud you’ve been listening to music over time and offers ways to adjust to help you maintain your hearing wellness<br/>Gaming audio now reaches your ears up to 2x faster on average; when you start a game, your earbuds automatically switch to gaming mode, cutting latency in half[4]<br/>The battery keeps up with your life, with up to 11 hours of listening time, or up to 31 hours with the charging case[5]; you can charge them wirelessly with Pixel Stand or other Qi-certified chargers[6]<br/>Transparency mode helps you hear outside sounds in real time so you can be more aware of your surroundings, like when crossing the street; Conversation Detection pauses your music and your earbuds switch to Transparency mode when you start speaking<br/>Show more<br/> Report an issue with this product or seller<br/>Note: Products with electrical plugs are designed for use in the US. Outlets and voltage differ internationally and this product may require an adapter or converter for use in your destination. Please check compatibility before purchasing.](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHUEIGmSwGmEDBS9DFGWlAP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_amazon-com-google-pixel-buds-pro-noise-canceling-earbuds-up-to-31-hour-battery-life-with-charging-case2-bluetooth.webp "About this item<br/>Pixel Buds Pro use Active Noise Cancellation with Silent Seal to adapt to your ear and help block outside sounds, creating a quiet foundation so your music can shine; and now they’re even better, with new features and colors<br/>With double the bandwidth for clearer calls, Pixel Buds Pro are the perfect earbuds for Pixel[11]<br/>Pairs with any Bluetooth 4.0+ device, including Android, iOS, tablets, and laptops[1]; and multipoint connectivity helps you switch between compatible devices, so you can go from listening to music on your phone to taking a call on your laptop[2]<br/>Pixel Buds Pro have custom 11 mm speaker drivers and Volume EQ to sound amazing at any volume[3]; the app tells you how loud you’ve been listening to music over time and offers ways to adjust to help you maintain your hearing wellness<br/>Gaming audio now reaches your ears up to 2x faster on average; when you start a game, your earbuds automatically switch to gaming mode, cutting latency in half[4]<br/>The battery keeps up with your life, with up to 11 hours of listening time, or up to 31 hours with the charging case[5]; you can charge them wirelessly with Pixel Stand or other Qi-certified chargers[6]<br/>Transparency mode helps you hear outside sounds in real time so you can be more aware of your surroundings, like when crossing the street; Conversation Detection pauses your music and your earbuds switch to Transparency mode when you start speaking<br/>Show more<br/> Report an issue with this product or seller<br/>Note: Products with electrical plugs are designed for use in the US. Outlets and voltage differ internationally and this product may require an adapter or converter for use in your destination. Please check compatibility before purchasing."){kind=tracking}
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_biden-signs-executive-order-capping-number-of-asylum-seekers-at-us-mexico-border.webp "Biden Signs Executive Order , Capping Number of <br/>Asylum Seekers , at US-Mexico Border.<br/>Biden Signs Executive Order , Capping Number of <br/>Asylum Seekers , at US-Mexico Border.<br/>On June 4, President Joe Biden signed an <br/>executive order restricting asylum seekers <br/>at the United States' border with Mexico.<br/>On June 4, President Joe Biden signed an <br/>executive order restricting asylum seekers <br/>at the United States' border with Mexico.<br/>'Newsweek' report that the executive order utilizes <br/>a controversial regulation last used by his <br/>predecessor, former President Donald Trump.<br/>'Newsweek' report that the executive order utilizes <br/>a controversial regulation last used by his <br/>predecessor, former President Donald Trump.<br/>The executive order will effectively halt migrants crossing <br/>the U.S. border once a daily cap of 2,500 crossings per <br/>day over a seven-day average has been reached. .<br/>The executive order will effectively halt migrants crossing <br/>the U.S. border once a daily cap of 2,500 crossings per <br/>day over a seven-day average has been reached. .<br/>It also allows officials to rapidly deport <br/>migrants who cross the border illegally.<br/>We will need to review the executive <br/>order before making litigation <br/>decisions, but any policy that <br/>effectively shuts off asylum would <br/>raise obvious legal problems,<br/> just as we did when the Trump <br/>administration tried to end asylum,Lee Gelernt, Deputy director of the ACLU's <br/>Immigrants' Rights Project, via 'Newsweek'.<br/>'Newsweek' reports that the executive order <br/>marks a significant shift in the Biden <br/>administration's immigration policy. .<br/>'Newsweek' reports that the executive order <br/>marks a significant shift in the Biden <br/>administration's immigration policy. .<br/>The executive order utilizes a law referred to as Section <br/>212(f), which dates back to the 1950s, and was last used <br/>by Donald Trump at the beginning of his presidency. .<br/>The executive order utilizes a law referred to as Section <br/>212(f), which dates back to the 1950s, and was last used <br/>by Donald Trump at the beginning of his presidency. .<br/>The measure allows the president to <br/>suspend the entry of any foreigner deemed <br/>\")
_my-little-girl-episode-27-long-version.webp "Oyku (Beren Gokyildiz) is an 8-year-old girl who has a very clear perception and is very smart, unlike her peers. When her aunt, with whom she has lived since birth, leaves her, she has to find her father Demir, whom she has never seen before. Demir (Bugra Gulsoy), a fraudster who grew up in an orphanage, is arrested on the day that Oyku comes to find him. Demir is released by the court on condition that he takes care of his daughter, but Demir does not want to live with Oyku. While Demir and his partner Ugur (Tugay Mercan) are trying to get rid of Oyku, they are planning to make a big hit. Candan (Leyla Lydia Tugutlu), who is the target of this great hit, hides the great pains of the past in her calm life. None of these people whom life will bring together with all these coincidences know that Oyku is hiding a great secret.<br/><br/>CAST: Bugra Gulsoy, Leyla Lydia Tugutlu, Beren Gokyildiz, Serhat Teoman, Tugay Mercan, Sinem Unsal, Suna Selen.<br/><br/>CREDITS<br/>PRODUCTION COMPANY: MED Yapim<br/>PRODUCER: Fatih Aksoy<br/>DIRECTOR: Gokcen Usta")
_mein-episode-09.webp "Mein-Episode-09<br/><br/>Mein | The Quest Of Me With Me<br/><br/>Mein is a dramatic story of two strong-headed individuals who end up crossing paths due to being unlucky in love while facing family and societal pressures!<br/><br/>Directed By: Badar Mehmood<br/>Written By: Zanjabeel Asim Shah<br/><br/>Cast:<br/>Wahaj Ali<br/>Ayeza Khan<br/>Azeekah Daniel<br/>Usman Peerzada<br/>Shehzad Nawaz<br/>Aijaz Aslam<br/>Agha Mustafa<br/>Nameer Khan<br/>Sabeena Syed<br/>Alizay Rasool<br/>Rohi Ghazali<br/>Shiza Khan")
_my-little-girl-episode-29-long-version.webp "Oyku (Beren Gokyildiz) is an 8-year-old girl who has a very clear perception and is very smart, unlike her peers. When her aunt, with whom she has lived since birth, leaves her, she has to find her father Demir, whom she has never seen before. Demir (Bugra Gulsoy), a fraudster who grew up in an orphanage, is arrested on the day that Oyku comes to find him. Demir is released by the court on condition that he takes care of his daughter, but Demir does not want to live with Oyku. While Demir and his partner Ugur (Tugay Mercan) are trying to get rid of Oyku, they are planning to make a big hit. Candan (Leyla Lydia Tugutlu), who is the target of this great hit, hides the great pains of the past in her calm life. None of these people whom life will bring together with all these coincidences know that Oyku is hiding a great secret.<br/><br/>CAST: Bugra Gulsoy, Leyla Lydia Tugutlu, Beren Gokyildiz, Serhat Teoman, Tugay Mercan, Sinem Unsal, Suna Selen.<br/><br/>CREDITS<br/>PRODUCTION COMPANY: MED Yapim<br/>PRODUCER: Fatih Aksoy<br/>DIRECTOR: Gokcen Usta")
_crossing-trailer.webp "MUBI has released a new trailer and artwork for Levan Akin’s (And Then We Danced, Sweden’s 2019 Academy Award® entry) latest feature film, Crossing. A moving, compassionate tale of identity, acceptance and unlikely connection that transcends borders and generations, the film will be released in cinemas in the UK and Ireland on 19 July 2024.<br/><br/>Lia, a retired school teacher living in Georgia, hears from a young neighbour Achi that her long lost niece Tekla, a transgender woman, has crossed the border into Turkey. Hoping to bring Tekla home after a period of estrangement, Lia travels to Istanbul with the unpredictable Achi to find her. Exploring the hidden depths of the city, they cross paths with a transgender lawyer called Evrim, who helps them in their search. Humanistic and tender, Akin’s third feature is a heartfelt portrayal of overcoming the degrees of separation that divide us.<br/><br/>Written by Akin, Crossing stars Mzia Arabuli, Lucas Kankava and Deniz Dumanlı, with cinematography from Lisabi Fridell (And Then We Danced), production design by Roger Rosenberg (The Worst Person in the World) and co-edited by Levan Akin and Emma Lagrelius.<br/><br/>Crossing opened the Panorama section at the 2024 Berlinale for its World Premiere in February, where it was awarded the Teddy Prize Jury Award and received its UK Premiere at the BFI Flare Film Festival in March 2024.")
_revealing-a-secret-on-nbc39s-chicago-med.webp "Immerse yourself in the intensity of the “Revealing a Secret” clip from NBC's gripping medical drama, Chicago Med. In Season 9, viewers are drawn into the high-stakes world of the Chicago Med team as they navigate complex medical cases and personal challenges. This season highlights the exceptional storytelling of creators Dick Wolf and Matt Olmstead, known for Law & Order. Featuring a stellar cast including Oliver Platt, Steven Weber, Jessy Schram and more, Chicago Med delivers heart-pounding action and an emotional rollercoaster. Catch the latest episodes of Chicago Med Season 9, now streaming on Peacock!<br/><br/>Chicago Med Cast:<br/><br/>Marlyne Barrett, S. Epatha Merkerson, Oliver Platt, Lorena Diaz, Courtney Rioux, Dominic Rains, Jeremy Shouldis, Steven Weber, Cesar Jaime, Marie Tredway, Luke Mitchell, Henderson Wade and Jessy Schram<br/><br/>Stream Chicago Med Season 9 now on Peacock!")
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