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How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
How to do a testosterone or estrogen injection – LGBTQ Clinic
⏲ 7 minutes 43 seconds 👁 592.8K
Types of injection : Sites& Techniques - Intra muscular Intra dermal Subcutaneous
⏲ 5 minutes 49 seconds 👁 454.4K
Genta-Combisone injection for Chickens _ Poultry Birds and Large Animals
⏲ 3:49 👁 10K
SEMAGLUTIDE INJECTION
⏲ 2 minutes 18 seconds 👁 240.8K
Epidural Steroid Injections for Chronic Back Pain
⏲ 3 minutes 19 seconds 👁 428.7K
We Modernised A 1950s Ford F100
⏲ 4:31 👁 10K
Cortisone Injections - How They Work and When to Avoid Them
⏲ 6 minutes 57 seconds 👁 50.1K
Back Pain: Before and After Steroid Injections
⏲ 2 minutes 53 seconds 👁 133K
Eye S-troke Symptoms Risk and Treatment, Prevention Tips By Doctor. Harsh Mone|Boldsky
⏲ 4:14 👁 1.2M
What You Should Know: Lumbar Epidural Steroid Injections
⏲ 5 minutes 2 seconds 👁 107.1K
Platelet-Rich Plasma (PRP) Injections | Q&A
⏲ 2 minutes 54 seconds 👁 159.2K
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![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_how-to-do-a-testosterone-or-estrogen-injection-lgbtq-clinic.webp "University of Iowa Health Care")
_types-of-injection-sites-amp-techniques-intra-muscular-intra-dermal-subcutaneous.webp "Dr.G Bhanu Prakash Animated Medical Videos")
_genta-combisone-injection-for-chickens---poultry-birds-and-large-animals.webp "Genta-Combisone injection for Chickens _ Poultry Birds and Large Animals<br/><br/>#veterinay<br/>#medicine<br/>#disease<br/>#animallovers<br/>#petlover<br/>#petcare<br/>#trainyourpet")
_semaglutide-injection.webp "North Texas Plastic Surgery")
_epidural-steroid-injections-for-chronic-back-pain.webp "UC San Diego Health")
_we-modernised-a-1950s-ford-f100.webp "BROTHERS Mike and Jim Ring from Spring Green, Wisconsin, are two custom car building legends known as 'The Ringbrothers'. One of their finest builds is a 1956 Ford F100 truck which took an impressive 3,000 hours to build spread over seven months, costing over $85,000 in parts alone. Powering the truck is a 415-horsepower 5.0-liter Ford Coyote crate motor which is a really good fit for the 50s pickup. With a 1956 cab, but a 1954 grill, the truck is actually a mixture of the two, however the brothers explain: “Most people will recognize it as a ‘56 just because of the cab.” Whilst this vehicle has the looks of a 50s masterpiece, The Ringbrothers are known for blending old-school looks with modern technology. The 1956 Ford F100 is not short of up to date tech either - it has power brakes, electronic transmission, fuel injection, air conditioning and even a bluetooth stereo system. “There’s a lot of modern amenities that you would probably never pick up on by just walking by it,” Jim adds. The car’s interior also sports a classic 50s look, not giving away any of the modern conveniences the brothers have added. Mike says: \")
_cortisone-injections-how-they-work-and-when-to-avoid-them.webp "Sports Injury Physio")
_back-pain-before-and-after-steroid-injections.webp "RAYUS Radiology™")
_eye-s-troke-symptoms-risk-and-treatment-prevention-tips-by-doctor-harsh-mone124boldsky.webp "Eye S-troke Symptoms: बढ़ती गर्मी के कारण जो हवाएं चलती है, उनमें गर्माहट रहती है जो चेहरे और आंखों पर लगने से बुरा प्रभाव डालती है.तो ऐसे में ऑय स्ट्रोक क्या होता है, इसके सिम्पटम्स क्या है सब जानेगे डॉक्टर हर्ष मोने से. <br/> <br/>Eye S-troke Symptoms: Due to increasing heat, the winds that blow contain heat which has a bad effect on the face and eyes.So in such a situation, what is eye s-troke and what are its symptoms, everyone will know from Dr. Harsh Mone. <br/> <br/> <br/>#EyeS-trokeSymptoms, #EyeS-trokeTreatment,#EyeS-trokeRecoveryTime,#EyeS-trokeInstatntRelief,#DoctorsAdvice,#EyeS-trokePrevention <br/><br/>~HT.97~PR.266~ED.120~")
_what-you-should-know-lumbar-epidural-steroid-injections.webp "NASSspine")
_platelet-rich-plasma-prp-injections-124-qampa.webp "Johns Hopkins Medicine")
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