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_beautiful-naat-shahbaz-qamar-fareedi.jpg "#bismillahProduction #<br/>Label - BISMILLAH PRODUCTOIN<br/><br/>Contact Channel No. : +92 321 8851272<br/><br/><br/>Umeed karta hu ye video aap ko pasand aye gi, LIKE kren aur doston ke sath zrur SHARE kren. <br/><br/>#Bismillah_Production<br/><br/>------------------------------------------------------<br/><br/>DISCLAIMER: This Channel DOES NOT Promote or encourage Any illegal activities , all contents provided by This Channel is meant for EDUCATIONAL PURPOSE only .<br/><br/><br/><br/>Please like - subscribe and Share.")
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_watch-yugioh-vrians-season-1-for-free-link-in-description.jpg "If you are interested in watching yugioh vrians season 1 for free then<br/>Click here: https://clk.wiki/Yugioh<br/>About anime:<br/>The Yu-Gi-Oh! universe expands with this story about a hero who battles hackers in cyberspace in private while appearing to be a quiet high schooler.<br/>Starring:Jake PaqueEmily CarmerDaniel J. EdwardsDanny KramerMark Schenfisch<br/>Directed by:Cameron Sharp<br/>If you are interested in watching new intresting anime and movies then follow this channel<br/>")
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_proud-be-father.jpg "Har tara ki videos upload hon gi please like share videos")
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![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.jpg "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
⏲ 1:42 👁 10K
_rocco-nacino-nanalo-ng-gold-at-bronze-medal-sa-2024-pan-asian-gi-and-no-gi-international-open-124-unang-balita.jpg "Unang Balita is the news segment of GMA Network's daily morning program, Unang Hirit. It's anchored by Arnold Clavio, Susan Enriquez, Ivan Mayrina, and Mariz Umali, and airs on GMA-7 Mondays to Fridays at 5:30 AM (PHL Time). For more videos from Unang Balita, visit http://www.gmanetwork.com/unangbalita.<br/><br/>#GMAIntegratedNews #KapusoStream<br/><br/>Breaking news and stories from the Philippines and abroad:<br/>GMA Integrated News Portal: http://www.gmanews.tv<br/>Facebook: http://www.facebook.com/gmanews<br/>TikTok: https://www.tiktok.com/@gmanews<br/>Twitter: http://www.twitter.com/gmanews<br/>Instagram: http://www.instagram.com/gmanews<br/><br/>GMA Network Kapuso programs on GMA Pinoy TV: https://gmapinoytv.com/subscribe")
⏲ 1:15 👁 130K
_friendship-karo-gi--comments-trolling.jpg "Friendship karo gi? Comments Trolling in Pakistan")
⏲ 6:32 👁 5K
_abbott-amp-costello-in-gi-jokers-fr0m-the-iceberg-lounge.jpg "ABBOTT & COSTELLO IN gi jokersFR0M THE ICEBERG LOUNGE from gi 7jmtsoqo")
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_art-beautiful-cute-art.jpg "Har tara ki videos upload hon gi please like share videos")
⏲ 0:16 ✓ 08-Jun-2024
_oh-bhaiya-ma-to-kuwari-reh-lo-gi.jpg "Comedy & Entertainment Channel created by Nauman Rafiq for Having lot of fun for people")
⏲ 0:11 ✓ 08-Jun-2024
_abbott-amp-costello-in-gi-jokers-fr0m-the-iceberg-lounge.jpg "ABBOTT & COSTELLO IN gi jokersFR0M THE ICEBERG LOUNGE from gi 7jmtsoqo")
⏲ 4:49 ✓ 07-Jun-2024
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_beautiful-naat-shahbaz-qamar-fareedi.webp "#bismillahProduction #<br/>Label - BISMILLAH PRODUCTOIN<br/><br/>Contact Channel No. : +92 321 8851272<br/><br/><br/>Umeed karta hu ye video aap ko pasand aye gi, LIKE kren aur doston ke sath zrur SHARE kren. <br/><br/>#Bismillah_Production<br/><br/>------------------------------------------------------<br/><br/>DISCLAIMER: This Channel DOES NOT Promote or encourage Any illegal activities , all contents provided by This Channel is meant for EDUCATIONAL PURPOSE only .<br/><br/><br/><br/>Please like - subscribe and Share.")
_watch-yugioh-vrians-season-1-for-free-link-in-description.webp "If you are interested in watching yugioh vrians season 1 for free then<br/>Click here: https://clk.wiki/Yugioh<br/>About anime:<br/>The Yu-Gi-Oh! universe expands with this story about a hero who battles hackers in cyberspace in private while appearing to be a quiet high schooler.<br/>Starring:Jake PaqueEmily CarmerDaniel J. EdwardsDanny KramerMark Schenfisch<br/>Directed by:Cameron Sharp<br/>If you are interested in watching new intresting anime and movies then follow this channel<br/>")
_proud-be-father.webp "Har tara ki videos upload hon gi please like share videos")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_rocco-nacino-nanalo-ng-gold-at-bronze-medal-sa-2024-pan-asian-gi-and-no-gi-international-open-124-unang-balita.webp "Unang Balita is the news segment of GMA Network's daily morning program, Unang Hirit. It's anchored by Arnold Clavio, Susan Enriquez, Ivan Mayrina, and Mariz Umali, and airs on GMA-7 Mondays to Fridays at 5:30 AM (PHL Time). For more videos from Unang Balita, visit http://www.gmanetwork.com/unangbalita.<br/><br/>#GMAIntegratedNews #KapusoStream<br/><br/>Breaking news and stories from the Philippines and abroad:<br/>GMA Integrated News Portal: http://www.gmanews.tv<br/>Facebook: http://www.facebook.com/gmanews<br/>TikTok: https://www.tiktok.com/@gmanews<br/>Twitter: http://www.twitter.com/gmanews<br/>Instagram: http://www.instagram.com/gmanews<br/><br/>GMA Network Kapuso programs on GMA Pinoy TV: https://gmapinoytv.com/subscribe")
_friendship-karo-gi--comments-trolling.webp "Friendship karo gi? Comments Trolling in Pakistan")
_abbott-amp-costello-in-gi-jokers-fr0m-the-iceberg-lounge.webp "ABBOTT & COSTELLO IN gi jokersFR0M THE ICEBERG LOUNGE from gi 7jmtsoqo")
_art-beautiful-cute-art.webp "Har tara ki videos upload hon gi please like share videos")
_oh-bhaiya-ma-to-kuwari-reh-lo-gi.webp "Comedy & Entertainment Channel created by Nauman Rafiq for Having lot of fun for people")
_abbott-amp-costello-in-gi-jokers-fr0m-the-iceberg-lounge.webp "ABBOTT & COSTELLO IN gi jokersFR0M THE ICEBERG LOUNGE from gi 7jmtsoqo")
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