Quizartinib for FLT3-ITD positive AML after second-line chemo or stem cell transplant from flt3 itd mutation positive Watch Video

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⏲ Duration: 3 min 26 sec
✓ Published: 16-Jan-2018
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Research suggests that a new targeted therapy, quizartinib, may be a safe and effective option to treat a subset of patients with treatment-resistant acute myeloid leukaemia (AML), whose leukaemia has the FLT3-ITD mutation.nnQuizartinib is the first and only single-agent drug that has produced a clinical benefit in AML patients with this deadly mutation who have failed previous therapy.nnThe number of patients bridged to a stem cell transplant was very significant. Dr Levis and his colleagues pl

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Presented by Mark J. Levis, MD, PhD nnDr. Levis presents results of the QuANTUM-R trial, the first positive phase 3 trial to demonstrate improved OS with single-agent quizartinib in the R/R FLT3-ITD AML setting compared with salvage chemotherapy. The data confirm the safety and efficacy of quizartinib and the value of targeting the FLT3-ITD driver mutation with a highly potent and selective FLT3 inhibitor.
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Dr Harry Erba speaks to ecancer at the EHA 2022 meeting about quizartinib improving the overall survival in adult patients with FLT3-ITD+ acutenmyeloid leukaemia.nn Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults, and approximately 25% of all newly diagnosed cases carry the FLT3-internal tandem duplication (ITD) gene mutation.nnThe results showed that the addition of quizartinib significantly improved overall survival compared with standard induction and consolidation
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